UNVEILING THE PATHOGENIC MECHANISMS OF NPR2 MISSENSE VARIANTS: INSIGHTS INTO THE GENOTYPE-ASSOCIATED SEVERITY IN ACROMESOMELIC DYSPLASIA AND SHORT STATURE

Introduction: Natriuretic peptide receptor 2 (NPR2 or NPR-B) plays a central role in growth development and bone morphogenesis and therefore loss-of-function variations in NPR2 gene have been reported to 4 post backdrop stand cause Acromesomelic Dysplasia, Maroteaux type 1 and short stature.While several hypotheses have been proposed to underlie th

In current-generation designs of total primary hip joint replacement, the prostheses are fabricated from alloys.The modulus of elasticity of the alloy is substantially higher than that of the surrounding bone.This discrepancy plays a role in a phenomenon known as stress shielding, in which the bone bears a reduced proportion of the applied load.Str

Eighteen one-hump black (Majaheem) young camels were used to study growth rate and carcass percentage.The animals were selected and bought of similar age (about six months) and weight (around 150 kg).They were assigned randomly into three feeding groups.Each group was fed two types of rations: (A) concentrated pellets 18% crude protein at the rate